![]() ![]() To look at early amyloid pathology in cognitively healthy (CH) individuals, we used cerebrospinal fluid (CSF) measures of amyloid and tau after extensive neuropsychometric testing revealed no cognitive impairment. ![]() Īmyloid pathology is recognized many years before symptomatic or behavioral changes and are early biomarkers of AD. Analysis of brain activity changes from baseline to the active stage during a cognitive challenge may be helpful to better understand the dynamic abnormalities of information processing in early Alzheimer’s disease (AD) pathology, as has been studied in other neurological conditions, such as schizophrenia, mTBI, migraine, and symptomatic AD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.īrain challenge using cognitive tasks have been used to study dynamic brain activities during processing of external information. Whittier Foundation 2011-2017, MGH NIA P01 AG052350, MGH HMRI, XA Alexander Family Foundation, MGH the Pfeiffer Research Foundation, MGH and the Jerry Dunlevy Family Foundation, MGH. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This research was funded by the L.K. Received: JAccepted: NovemPublished: January 2, 2019Ĭopyright: © 2019 Arakaki et al. Ginsberg, Nathan S Kline Institute, UNITED STATES This study provide pilot information to further evaluate whether this biomarker has clinical significance.Ĭitation: Arakaki X, Lee R, King KS, Fonteh AN, Harrington MG (2019) Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals. Additional power and correlations with behavioral performance were also explored. The alpha ERD and SE analyses suggest there is frontal lobe dysfunction during WM processing in the CH-PAT stage. Alpha SE did not change in CH-NATs, but was increased from baseline in the CH-PATs in frontal and left lateral regions (p<0.01), and was higher in the frontal region (p<0.01) of CH-PATs compared to CH-NATs. ![]() ![]() During 0-back WM testing, the behavioral performance was similar between the two groups, however, qEEG notably differentiated CH-PATs from CH-NATs on the simple, 0-back testing: Alpha ERD decreased from baseline only in the parietal region in CH-NATs, while it decreased in all brain regions in CH-PATs. We recorded behavioral performances, and analyzed alpha power and alpha spectral entropy (SE) at three occasions: during the resting state, and at event-related desynchronization (ERD) during 0-back and 2-back. We studied 60–100 year old participants, with normal cognition, and who fits one of two subgroups from cerebrospinal fluid (CSF) proteins: cognitively healthy (CH) with normal amyloid/tau ratio (CH-NAT, n = 10) or pathological amyloid/tau ratio (CH-PAT, n = 14). We used quantitative electroencephalography (qEEG) to investigate brain activities during N-back working memory (WM) processing at two different load conditions (N = 0 or 2) in an aging cohort. Our aim is to explore if cognitive challenge combined with objective physiology can reveal abnormal frontal alpha event-related desynchronization (ERD), in early Alzheimer’s disease (AD). ![]()
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